Metformin improves cancer immunotherapy by directly rescuing tumor-infiltrating CD8 T lymphocytes from hypoxia-induced immunosuppression.

Veronica Finisguerra,Tereza Dvorakova, Matteo Formenti, Pierre Van Meerbeeck,Lionel Mignion,Bernard Gallez,Benoit J Van den Eynde

Journal for immunotherapy of cancer（2023）

Cited 1|Views9

No score

Abstract

This study describes a novel mechanism of action of metformin and presents a promising strategy to achieve immune rejection in hypoxic and immunosuppressive tumors, which would otherwise be resistant to immunotherapy.

Translated text

Key words

cancer immunotherapy,metformin,immunosuppression,tumor-infiltrating,hypoxia-induced

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined