Assessment of the reliability of MSI status and dMMR proteins deficiency screening on endoscopic biopsy material in esophagus and gastric adenocarcinoma.

Nicolas Asesio,Nozha Mhamdi Aloui,Julie Bonnereau,Jacqueline Lehmann-Che,Fatiha Bouhidel,Rachid Kaci,Hélène Corte,Magali Svrcek,My Linh Tran Minh,Jean Marc Gornet,Pierre Cattan, Matthieu Allez,Philippe Bertheau, Thomas Aparicio

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver（2023）

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摘要

By comparison of dMMR phenotype obtained by immunohistochemistry and MSI status by PCR between match-paired samples of oesogastric cancer's endoscopic biopsies and surgical specimen, we observed that biopsies are a suitable source of tissue for dMMR/MSI status determination.

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关键词

Oeso-gastric adenocarcinoma,Microsatellite instability,Endoscopic biopsy,Immunohistochemistry,Diagnosis

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