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Genomic and transcriptomic features between primary and paired metastatic fumarate hydratase-deficient renal cell carcinoma.

Jiayu Liang,Guangxi Sun,Xiuyi Pan,Mengni Zhang,Pengfei Shen,Sha Zhu,Jinge Zhao,Linmao Zheng,Junjie Zhao,Yuntian Chen,Xiaoxue Yin,Junru Chen,Xu Hu,Yuhao Zeng,Jianhui Chen,Yongquan Wang,Zhihong Liu,Jin Yao,Minggang Su,Rui Huang,Banghua Liao,Qiang Wei,Xiang Li,Qiao Zhou,Jiyan Liu,Yali Shen,Zhenhua Liu,Ni Chen,Hao Zeng,Xingming Zhang

Genome medicine（2023）

Cited 1|Views34
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Abstract
Overall, our study demonstrated the genomic, epigenomic, and transcriptomic features of metastatic lesions in FH-RCC and revealed their early evolutionary trajectory. These results provided multi-omics evidence portraying the progression of FH-RCC.
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Key words
Fumarate hydratase-deficient renal cell carcinoma, Whole-exome sequencing, DNA methylation, RNA-seq, Tumor evolution, Metastatic lesions
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