Urate-Lowering Therapy Inhibits Thoracic Aortic Aneurysm and Dissection Formation in Mice.
Arteriosclerosis, thrombosis, and vascular biology(2023)
Abstract
This study uncovered an important and previously unrecognized role of hyperuricemia in mediating the pathogenesis of TAAD, and uric acid-lowering drug may represent a promising therapeutic approach for TAAD.
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Key words
aortic aneurysm, thoracic, aortic dissection, allopurinol, hyperuricemia, inflammation, receptors, IgG
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