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Cytochrome P450 oxidoreductase, POR, associated with severe paclitaxel-induced peripheral neuropathy in patients of European ancestry from ECOG-ACRIN E5103.

Fei Shen,Guanglong Jiang,Santosh Philips,Laura Gardner,Gloria Xue,Erica Cantor,Reynold C Ly,Wilberforce Osei,Xi Wu,Chau Dang,Donald Northfelt,Todd Skaar,Kathy D Miller,George W Sledge,Bryan P Schneider

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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Abstract
Rare variants in POR, predict an increased risk of severe TIPN in patients of European ancestry who receive paclitaxel.
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