Extrachromosomal circular MiR-17-92 amplicon promotes hepatocellular carcinoma.

Sailan Zou, Shihan Chen, Guocheng Rao,Guixiang Zhang,Meilin Ma,Boqiang Peng,Xiao Du,Wei Huang,Weiqiang Lin, Yan Tian,Xianghui Fu

Hepatology (Baltimore, Md.)（2023）

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摘要

These findings delineate the genome-wide eccDNAs profiling of HCC and highlight the functional significance of microRNA-containing eccDNAs in tumorigenesis, providing insight into HCC pathogenesis and cancer therapy, as well as eccDNA and microRNA biology.

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