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Efficacy of a 4-Antigen Staphylococcus aureus Vaccine in Spinal Surgery: The STRIVE Randomized Clinical Trial.

Hamid Hassanzadeh,James Baber,Elizabeth Begier, David C Noriega,Hiroaki Konishi,Yoshiyuki Yato,Michael Y Wang,Jean Charles Le Huec,Vikas Patel,Peter Varga,Ulf Liljenqvist,John Conly,Charu Sabharwal,Iona Munjal,David Cooper,David Radley,Anna Jaques,Michael Patton,William C Gruber,Kathrin U Jansen,Annaliesa S Anderson,Alejandra Gurtman

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2023）

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Abstract
In patients undergoing elective spinal fusion surgical procedures, SA4Ag was safe, well tolerated, but despite eliciting substantial antibody responses that blocked key S aureus virulence mechanisms, was not efficacious in preventing S aureus infection. ClinicalTrials.gov: NCT02388165.
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