Genetic variants of G-protein coupled receptors associated with pubertal disorders.
Reproductive medicine and biology（2023）
Abstract
The six GPCRs in the HPG axis govern pubertal development through fine-tuning of hormone secretion. Rare sequence variants in these genes jointly account for a certain percentage of genetic causes of pubertal disorders. Still, much remains to be clarified about the molecular network involving the six GPCRs.
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Key words
gene, G-protein coupled receptor, hypothalamic-pituitary-gonadal axis, puberty, variant
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