Multi-enzyme mimetic iridium nanozymes-based thrombus microenvironment-modulated nanoplatform for enhanced thrombolytic therapy

Meng Huang,Yuda Zhu,Guang Xin,Yilan Wang, Fan Li,Shiyi Li,Yuman Dong,Kun Zhang,Lijuan Feng,Li Tang,Boli Zhang,Wen Huang

Chemical Engineering Journal（2023）

引用 1|浏览20

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摘要

•A thrombolytic nanoplatform with anti-inflammation and ROS scavenging is prepared.•Iridium was first applied in regulating thrombotic microenvironment and bioimaging.•The nanoplatform achieved thrombotic microenvironment-responsive drug delivery.•The nanoplatform regulated the thrombotic microenvironment by Nrf2/HO-1 pathway.

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关键词

Iridium nanoparticles,Nanozyme,Antioxidant,Thrombus targeting,Thrombolysis therapy

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