Two‐step flow synthesis of Olaparib in microreactor: Route design, process development and kinetics research
Chemical Engineering Journal(2023)
摘要
•A two-step flow synthesis process of Olaparib was first developed.•An original monoacylation route for the synthesis of Olaparib was developed.•The reaction kinetics of monoacylation was investigated in microreactor.•The effects of key operating parameters for two steps were characterized.
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关键词
Olaparib, Microreactor, Flow synthesis, Monoacylation, Kinetics
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