Detection of anti-SARS-CoV-2 antibodies in tears: Ocular surface immunity to COVID-19

N. Guemes-Villahoz,B. Burgos-Blasco, P.L. Echevarria-Torres,B. Vidal-Villegas,A. Rodriguez de la Peña, D. Diaz-Valle,J.I. Fernández-Vigo,S. Sánchez-Ramón,J. Garcia-Feijoo

Archivos de la Sociedad Española de Oftalmología (English Edition)（2023）

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摘要

SARS-CoV-2-specific IgA and IgG antibodies were detected in tears after mild COVID-19, highlighting the role of the ocular surface as a first line of defense against infection. Most naturally infected unvaccinated individuals exhibit long-term specific IgA in tears and saliva. Hybrid immunization (natural infection plus vaccination) appears to enhance mucosal and systemic IgG responses. However, no differences were observed between the 2- and 3-dose vaccination schedule.

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Antibodies,COVID-19,Eye,IgA,IgG,Ocular surface,SARS-CoV-2

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