Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients

Sergej Nadalin,Lena Zatković,Vjekoslav Peitl,Dalibor Karlović,Branka Vidrih,Antonia Puljić,Sanja Dević Pavlić,Alena Buretić-Tomljanović

Prostaglandins, Leukotrienes and Essential Fatty Acids（2023）

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Abstract

•PLA2 gene polymorphisms are associated with antipsychotic medication treatment response.•PLA2G4A and PLA2G6 polymorphisms exerted significant but weak effects.•PLA2G4A polymorphism influences PANSS psychopathology.•PLA2G6 polymorphism influences PANSS psychopathology and metabolic parameters.•PLA2G4C polymorphism did not impact treatment response.

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Key words

Antipsychotic agents,Phospholipase A2,Polymorphism,Psychosis

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