A pilot pharmacogenetic study of calcium channel blocker treatment of bipolar mania

Miao Li,Ning Yuan,John I Nurnberger,Ney Alliey-Rodriguez,Jiaqi Zhou,Fangyuan Duan,Jiacheng Dai,Yu Chen,Jiaqi Lu, Li Xie,Fang Liu, Xuli Yang, Philippe Tapon, Vijay Gorrepati,Xuejun Liu,Chao Chen,Chunyu Liu,Elliot S Gershon

Psychiatry Research（2023）

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摘要

•A pilot study reports an association of polymorphisms of calcium channel genes and response to treatment of add-on calcium channel blocker (CCB) medication in bipolar disorder manic episodes.•SNPs rs2739258/rs2739260 AG-allele had a better treatment response to add-on CCB than those carrying the AA or GG genotypes.•SNPs residing in calcium channel genes could be predictors for add-on CCB treatment response of mania.

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