Synthesis of multi fluorine containing polyoxometalate sandwich type compound with drug delivery, DNA interaction and protein binding studies

•The synthesis and characterization of Polyoxometalate hybrid from newly synthesized fluorinated anhydride FDA-Di-Tris & FDA@Di-POM.•FDA@Di-POM showed comparatively better results for drug loading and drug release.•UV-visible study of FDA-Di-Tris and FDA@Di-POM with SS-DNA showed hypochromism trend which indicate intercalation mode of attachment.•Protein binding study presented binding constant value (Kb) FDA@Di-POM and FDA-Di-Tris, which are 2.28 × 108 M−1 and 1.55 × 108 M−1, correspondingly.