Galangin inhibits programmed cell death-ligand 1 expression by suppressing STAT3 and MYC and enhances T cell tumor-killing activity

Yi Zhong,Ming Yue Li, Lizhuo Han,Yi Tai, Shen Cao,Jiaxuan Li, Hanyu Zhao, Run Wang, Baojiang Lv, Zhida Shan,Hong Xiang Zuo,Lianxun Piao,Hong Lan Jin,Yue Xing,Xuejun Jin,Juan Ma

Phytomedicine（2023）

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摘要

•Identified galangin as an PD-L1 inhibitor at first time.•Galangin inhibits STAT3 by JAK1, JAK2, and SRC pathway.•Galangin inhibits MYC by Ras/RAF/MEK/ERK pathway.•Galangin blocks the interaction between STAT3 and MYC.•Galangin restores T-lymphocytes tumor-killing activity.

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关键词

stat3,cell,death-ligand,tumor-killing

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