Clinical aspects of spatially fractionated radiation therapy treatments

•Spatially fractionated radiation therapy (SFRT) can be a useful clinical modality for large or radioresistant tumors.•There is renewed interest in the clinical implementation of SFRT.•Dosimetric parameters associated with SFRT can be difficult to interpret without correlative outcomes data.•A successful SFRT program requires the multidisciplinary expertise and collaboration of physicians, physicists, dosimetrists, and radiation therapists.