Cinnabar-containing Chinese medicine Hua-Feng-Dan differs from mercury sulfide and mercury chloride in affecting gut microbiota in mice

Yong-Mei Liu,Bo Liu,Jie Liu,Shang-Fu Xu,Feng Zhang,Ming-Liang Cheng,Jing-Shan Shi

Pharmacological Research - Modern Chinese Medicine（2023）

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摘要

•Cinnabar (HgS) is included in Chinese medicines such as Hua-Feng-Dan.•The gut-brain axis promoted us to study mercury compounds on gut microbiota.•HgS and Hua-Feng-Dan did not affect intestinal histology and Hg accumulation.•Equal Hg content as HgCl2 produced mild inflammation and 20-fold Hg in intestine.•Hua-Feng-Dan differs from HgS or HgCl2 in affecting gut microbiota.

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关键词

Cinnabar-containing Hua-Feng-Dan,HgS,HgCl2,Intestine histology,Hg accumulation,Gut microbiota

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