ID: 206628 Neuromodulatory Effects of Medial Septum Theta-Stimulation on Hippocampal Neurons and Laminar Oscillations

Learning and memory requires coordinated communication within and between brain regions. These precise communications can manifest as oscillations in the local field potentials including theta and gamma frequencies. Disruption of these communications (e.g., traumatic brain injury) in the networks of the brain interfere with appropriate cognitive function. The adverse effects of such disruptions may be resolved using neuromodulation techniques that reinstate synchrony of brain oscillations essential for cognitive function. Prior studies have demonstrated that theta stimulation can improve spatial learning in injured animals. However, the effects of this stimulation on the neurons of the hippocampus or their local oscillations are unknown.