ID: 221898 MRI Compatible Device for Synchronized Synthesis of Multiple Carriers for Temporal Interference Stimulation

Temporal interference stimulation (TIS) [1] is considered a promising approach for non-invasive targeted modulation of deep brain region activity as it strongly reduces stimulation of overlaying structures and is more customizable than other transcranial electric stimulation methods. TIS is based on the beat frequency envelope of high frequency carriers. When the number of carriers and the complexity of the signal exceeds two, solutions based on signal generators and standalone current sources become increasingly difficult to synchronize to ensure coherent, phase-controlled modulation envelopes. The bandwidth and output impedance limitations of many available devices have prevented exploration of TIS beyond a few kHz. Magnetic resonance imaging (MRI) compatibility is also not fully provided with conventional solutions. Here, we sought to develop a highly flexible and safe device.