How to outsmart the cold tumor microenvironment: Design of STING ligand nanoparticles for improved cancer immunotherapy

Marija Petrovic,Stoyan Tankov,Martin Kiening,Yakkala Chakradhar,Duran Rafael,Paul R. Walker,Gerrit Borchard,Olivier Jordan

OpenNano（2023）

引用 0|浏览4

暂无评分

摘要

•Size of STING ligand nanocomplexes (NCs) is pH dependent, being 6-fold bigger than that of lysosomes at low pH.•Macrophage polarization from M2 to M1 upon STING ligand delivery might improve immune infiltration of cold tumors.•Biocompatibility and toxicity was assessed by hen egg CAM model.•Performed pilot in vivo STING ligand intratumoral administration studies on established B16.F10 tumor in mice.

查看译文

关键词

sting ligand nanoparticles,cold tumor microenvironment

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要