MLS analysis of INSIDE in-beam PET images for the detection of morphological changes in patients treated with protontherapy

Martina Moglioni,A.C. Kraan,A. Berti,P. Carra,P. Cerello, M. Ciocca,V. Ferrero,E. Fiorina, E. Mazzoni,M. Morrocchi,F. Pennazio,A. Retico,V. Rosso,G. Sportelli, V. Vitolo,M.G. Bisogni

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment（2023）

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摘要

Anatomical changes in proton therapy patients can affect the dose distribution and contribute to range uncertainty. In-beam Positron-Emission-Tomography (IB-PET) is a non-invasive technique that can be used to obtain information about morphological changes in the irradiated tissue. At the National Center of Oncological Hadrontherapy (CNAO) the INSIDE IB-PET scanner has acquired IB-PET data of eight proton treated patients enrolled for the clinical trial ID: NCT03662373. Our purpose is to assess the sensitivity of the INSIDE IB-PET system in detecting morphological changes by means of the Most-Likely-Shift (MLS) method.

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关键词

Clinical trial,In-beam PET,MC simulation,Morphological changes,Proton therapy,Range variations

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