Disruption of α-Synuclein Proteostasis in the Striatum and Midbrain of Long-term Ovariectomized Female Mice

•The relationship between α-Syn proteostasis and menopause is currently unknown.•Long-term ovariectomized mice showed an increase in α-Syn expression in striatum and midbrain.•Long-term ovariectomized mice exhibited impaired motor performance.•Long-term ovariectomized mice did not show any loss of nigral dopaminergic neurons.