Pallidal activities during sleep and sleep decoding in dystonia, Huntington's, and Parkinson's disease

Zixiao Yin,Yin Jiang,Timon Merk,Wolf-Julian Neumann,Ruoyu Ma,Qi An,Yutong Bai,Baotian Zhao,Yichen Xu,Houyou Fan,Quan Zhang,Guofan Qin, Ning Zhang, Jun Ma,Hua Zhang,Huanguang Liu,Lin Shi,Anchao Yang,Fangang Meng,Guanyu Zhu

Neurobiology of Disease（2023）

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摘要

•Pallidal activities during sleep are recorded in 39 patients with dystonia, HD, or PD.•Pallidal spectra and connectivity with cortex are modulated by sleep-wake transitions.•Differences in sleep-related activities may underly disease-specific abnormalities.•Pallidal activity-based ML decoder predicts sleep stages with accuracies of over 90%.•Decoding accuracies are influenced by the anatomical localization of the DBS lead.

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关键词

dystonia,parkinson,pallidal activities,huntington,sleep

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