Exploring the relation between reserve and fatigue in multiple sclerosis

Mario Tranfa, Valentina Virginia Iuzzolino,Pierpaolo Perrella,Antonio Carotenuto,Giuseppe Pontillo,Marcello Moccia,Sirio Cocozza,Andrea Elefante,Roberta Lanzillo,Arturo Brunetti,Vincenzo Brescia Morra,Maria Petracca

Multiple Sclerosis and Related Disorders（2023）

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摘要

•Fatigue affects MS patients regardless of demographic or clinical features.•Neither cognitive nor brain reserve protect from fatigue symptoms.•Fatigue is strictly linked to depressive symptoms.•There is need for new clinical tools to disentangle fatigue and depression in MS.

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