A comparative study of visual outcome in patients with optic neuritis treated with five or seven days of intravenous corticosteroid treatment

Guilherme Diogo Silva,Sara Terrim,Fernando Cavalcantide Sá e Benevides Falcão,Maria Alice Pimentel Falcão,Cleuber Esteves Chaves,Samira Apóstolos-Pereira,Ida Fortini,Márcia Rúbia Rodrigues Gonçalves,Luiz Roberto Comerlatti,Luiz Henrique Martins Castro,Dagoberto Callegaro,Mário Luiz Ribeiro Monteiro

Multiple Sclerosis and Related Disorders（2023）

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摘要

•We found similar frequency of visual impairment at 6–12 months in patients with ON treated with 5-day or 7-day duration of 1 g/d intravenous methylprednisolone treatment (IVMPT).•Corticosteroids comprise a genomic and non-genomic effect.•The ceiling effect of IVMP treatment may occur because the genomic effect is already in place at five days and, hence, the non-genomic effect does not provide additional benefit.

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optic neuritis,intravenous corticosteroid treatment,visual outcome

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