Lipid Nanoparticle Delivery Limits Antisense Oligonucleotide Activity and Cellular Distribution in the Brain after Intracerebroventricular Injection

Amy E. Byrnes,Sara L. Dominguez,Chun -Wan Yen,Benjamin I. Laufer,Oded Foreman,Mike Reichelt,Han Lin,Meredith Sagolla,Kathy Hoetzel,Hai Ngu,Christoffer Soendergaard,Alberto Estevez,Hsiu-Chao Lin,Alexandre Goyon,Juan Bian, Jessica Lin,Flora I. Hinz,Brad A. Friedman,Amy Easton,Casper C. Hoogenraad

MOLECULAR THERAPY-NUCLEIC ACIDS（2023）

Cited 6|Views31

Key words

MT: Delivery Strategies,antisense oligonucleotide,delivery,gymnosis,lipid nanoparticles,central nervous system,distribution,trafficking,immunoelectron microscopy

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