When the +1 nucleosome gets in the way, TFIIH fails but does not fall
Molecular Cell（2023）
Abstract
In this issue of Molecular Cell, Abril-Garrido et al.1 used cryo-EM to uncover that the +1 nucleosome inhibits transcription by interfering with the function of the TFIIH translocase via mechanisms that depend on its position relative to the transcription start site.
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