Mindfulness-based therapy regulates brain connectivity in major depression

Major depressive disorder (MDD) is associated with abnormal functional interactions among large-scale brain networks. Here we report findings from a randomized, active-controlled trial examining whether mindfulness-based therapy can regulate specific patterns of resting-state functional connectivity in clinically depressed patients. We show that a brief, clinically effective mindfulness intervention functionally decouples top-down control regions from brain areas implicated in sensory, affective, and attentional processing. While previous work has demonstrated the clinical impact of mindfulness training, the present findings shed light on the precise neural targets, providing new insight into the specificity of this therapeutic approach.