Small-molecule inhibitor of Fam20C in combination with paclitaxel suppresses tumor growth by LIF-JAK2/STAT3-modulated apoptosis in triple-negative breast cancer

•Fam20C inhibitor (3R) is in combination with paclitaxel for potential triple-negative breast cancer therapy.•The combination of Fam20C inhibitor (3R) and paclitaxel can induce TNBC cell apoptosis.•Fam20C inhibitor (3R) downregulates the expression of LIF and cyclin D1 in BT-549 cells.•Fam20C inhibitor (3R) and paclitaxel can regulate LIF-JAK2/STAT3 pathway in TNBC.