Bone marrow mesenchymal stem cell-derived exosomal miR-193b-5p reduces pyroptosis after ischemic stroke by targeting AIM2

•AIM2 is a target gene of miR-193b-5p.•Over expression of miR-193b-5p reduced pyroptosis and increased cell activity in OGD/R PC12 cells by AIM2 pathway.•miR-193b-5p-overexpressing exosomes had a greater effect in inhibiting AIM2 pathway-mediated pyroptosis in both in vivo and in vitro assays.•BMSC-Exos attenuate cerebral I/R injury by inhibiting AIM2 pathway-mediated pyroptosis through miR-193b-5p delivery.