Transdiagnostic behavioral and genetic contributors to repetitive negative thinking: A machine learning approach

•A machine learning ensemble method identified behavioral and genetic predictors of repetitive negative thinking (RNT).•Heightened response to aversive and fear inducing stimuli are associated with RNT.•The only genetic trait associated with RNT was polygenic risk score for neuroticism.•Our results warrant the exploration of interventions that target fear learning and interoceptive aversiveness.•Our results indicate that RNT is either a component of neuroticism or a contributor to the development and stability of it.