Improving Power and Accuracy in Randomized Controlled Trials of Pain Treatments by Accounting for Concurrent Analgesic Use

Pradeep Suri,Patrick J. Heagerty,Anna Korpak,Mark P. Jensen,Laura S. Gold,Kwun C.G. Chan,Andrew Timmons,Janna Friedly, Jeffrey G. Jarvik,Aaron Baraff

The Journal of Pain（2023）

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摘要

•Not accounting for analgesic use may decrease power and accuracy in pain trials.•This study examined several methods to account for analgesic use.•Most currently used methods resulted in decreased power and accuracy.•A novel outcome that accounts for analgesic use optimized power and minimized bias.

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关键词

Pain,opioids,low back pain,outcomes,power

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