Dexamethasone-sparing regimens with NEPA (netupitant/palonosetron) for the prevention of chemotherapy-induced nausea and vomiting in older patients (>65 years) fit for cisplatin: A sub-analysis from a phase 3 study.
Journal of Geriatric Oncology(2023)
摘要
This analysis shows that older-patients who are fit for cisplatin benefit from a simplified regimen of NEPA plus single-dose DEX with neither loss in antiemetic efficacy nor the adverse impact on patient daily functioning. The study was registered on ClinicalTrials.gov (identifier NCT04201769) on 17/12/2019 (retrospectively registered).
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关键词
Dexamethasone,Netupitant,Palonosetron,Cisplatin,CINV,Older patients,Neurokinin-1 receptor antagonist,Highly emetogenic chemotherapy
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