TFE3 gene rearrangement and protein expression contribute to a poor prognosis of renal cell carcinoma

Junyi Lin,Zhuang Tang, Chengjunyu Zhang,Wen Dong,Yeqing Liu, Hao Huang,Hao Liu,Jian Huang,Tianxin Lin, Xu Chen

Heliyon（2023）

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摘要

This is a novel finding that both FISH confirmed TFE3 gene rearrangement-mediated TFE3-rearranged RCC and IHC confirmed positive TFE3 protein expression [TFE3(+)] contribute to a poor prognosis in RCC, suggesting more active treatment and careful follow-up for TFE3(+) RCC patients. The combination of TFE3 and LVI may be a new risk stratification system for RCC.

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carcinoma

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