Exosomes derived from TGF-β1-pretreated mesenchymal stem cells alleviate biliary ischemia–reperfusion injury through Jagged1/Notch1/SOX9 pathway

Aimaiti Yasen, Jun Feng,Xing-Ming Xie, Kai Li, Yu-Hong Cai,Zhi-Hong Liao,Run-Bin Liang,Tian-Xing Dai,Guo-Ying Wang

International Immunopharmacology（2023）

引用 0|浏览5

暂无评分

摘要

•TGF-β1-pretreated MSCs have significant protective effects on intrahepatic biliary EpiCs.•TGF-β1-pretreatment enhanced MSCs-EXO production and its tissue repair ability.•MSCs-EXO exhibited therapeutic significance to biliary IRI.•EXO derived from TGF-β1-pretreated MSCs obviously alleviated biliary IRI.•EXO derived from TGF-β1-pretreated MSCs had apparent protective effects on biliary IRI through Jagged1/Notch/SOX9 pathway.

查看译文

关键词

mesenchymal stem cells,biliary ischemia–reperfusion,jagged1/notch1/sox9 pathway

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要