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Treatment of pregnant mice with ABZ had no effect on the immune response of their offspring infected with Trichinella spiralis

Shuhui Fan, Yue Wang,Ruigeng Ma,Tianming Niu,Boshi Zou,Yu Quan,Huinan Lu,Zhiyu Zhu,Chunwei Shi,Wentao Yang,Yanlong Jiang,Xin Cao,Jianzhong Wang,Haibin Huang,Yan Zeng,Nan Wang,Guilian Yang,Chunfeng Wang

International Immunopharmacology（2023）

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Abstract
•Albendazole treatment did not cause abortion in pregnant mice infected with T. spiralis.•Albendazole treatment during pregnancy promoted the Th2 and Treg immune responses in pregnant mice infected with T. spiralis.•Albendazole had no effects on the offspring survival rate, immune response or worm burden after T. spiralis infection.
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Key words
Trichinella spiralis,Pregnant mice,Immune response,Albendazole
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