Polygenic risk scores point toward potential genetic mechanisms of type 2 myocardial infarction in people with HIV
International Journal of Cardiology（2023）
摘要
•About half of myocardial infarction cases in people with HIV are type 2 (T2MI)•T2MI results from mismatch between myocardial oxygen supply and demand•Despite worse survival, evidence-based treatment recommendations are lacking•Polygenic risk scores implicated energy regulationand metabolic pathways in T2MI risk•Key genetic drivers of T2MI pathogenesismay help inform new therapeutic strategies
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