Glycyrrhizin protects against particulate matter-induced lung injury via regulation of endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis through Nrf2/HO-1/NQO1 signaling pathway

Qiangqiang Shi,Yao Qian,Beibei Wang,Li Liu,Yang Chen,Chengshui Chen, Lanfang Feng,Junjie Chen,Nian Dong

International Immunopharmacology（2023）

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摘要

•GL protects against PM-induced lung injury.•GL regulates endoplasmic reticulum (ER) stress and NLRP3 inflammasome-mediated pyroptosis to exert protective effect.•The Nrf2/HO-1/NQO1 anti-oxidative signaling pathway is responsible for the regulatory effet of GL on endoplasmic reticulum (ER) stress and NLRP3 inflammasome-mediated pyroptosis.

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