Knockdown of HMGB1 inhibits the crosstalk between oral squamous cell carcinoma cells and tumor-associated macrophages

Jinlin Wen,Panpan Yin,Ying Su,Feng Gao,Yanlin Wu,Wenbin Zhang, Peng Chi,Jiahui Chen,Xinyan Zhang

International Immunopharmacology（2023）

Cited 2|Views15

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Abstract

•HMGB1 in oral cancer cells affected tumor-associated macrophage polarization.•HMGB1 in macrophages affected the cocultured tumor cell proliferation and invasion.•Secreted HMGB1 regulted the crosstalk between tumor cells and macrophages.

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Key words

hmgb1,macrophages,carcinoma,tumor-associated

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