Inhibition of non-receptor tyrosine kinase LCK partially mitigates mixed granulocytic airway inflammation in a murine model of asthma

Saleh A. Alqarni,Sheikh F. Ahmad,Faleh Alqahtani,Naif O. Al-Harbi,Samiyah Alshehri,Khalid E. Ibrahim,Ali S. Alfardan,Sabry M. Attia,Ahmed Nadeem

International Immunopharmacology（2023）

引用 1|浏览13

暂无评分

摘要

•There are increased p-LCK levels in CD4+ T cells in mixed granulocytic asthma.•LCK inhibition significantly mitigates neutrophilic/eosinophilic inflammation.•LCK inhibition reduces mucus hypersecretion in mixed granulocytic asthma.•LCK inhibition attenuates Th2 and Th17 cells in mixed granulocytic asthma.

查看译文

关键词

Mixed granulocytic asthma, Oxidative inflammation, Lymphocyte specific protein tyrosine kinase, Th2 cells, Th17 cells, Neutrophils

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要