Neutrophils regulate tumor angiogenesis in oral squamous cell carcinoma and the role of Chemerin

Fei Gao,Yuanyong Feng,Xiaoyuan Hu,Xuan Zhang,Tongtong Li, Yueqi Wang,Shengyou Ge,Chengqin Wang,Jinghua Chi,Xiaohua Tan,Ning Wang

International Immunopharmacology（2023）

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摘要

•TANs count was positively correlated with MVD in oral squamous cell carcinoma.•Combination of TANs and MVD was better indicator for predicting OSCC patients’ prognosis than alone.•Chemerin promoted angiogenesis by upregulating proangiogenic factors in TANs via MEK/ERK pathway.•TANs and Chemerin may be potential therapeutic targets for inhibiting tumor angiogenesis in OSCC.

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