Flowability, binding and release property of “self-lubricating” microcrystalline cellulose
Industrial Crops and Products(2023)
摘要
Microcrystalline cellulose (MCC) has been widely used as an excipient in tablets. Silicified microcrystalline cellulose (SMCC) has more application than MCC by using silicon dioxide (SiO2) as a lubricant. However, findings show that the silicon dioxide (SiO2) nanoparticle component is a physiological hazard. In our research, “self-lubricating” microcrystalline cellulose (MCC) was developed by a ball-milling treatment. Commercial MCC and undried MCC with 60% or 80% moisture content were ball-milled for 12 or 24 h. After ball milling, ellipsoid-like particles, with wrinkled surfaces, and a broader particle size distribution resulted in a balance between the flowability and tabletability of the treated MCC. FTIR and XRD analysis showed that cellulose Ⅱ was formed in the undried 60% moisture content MCC after ball milling for 12 or 24 h, which improved the burst disintegration ability of the tablets. In addition, the controlled-released MCC has also been developed. AFM patterns and the angle of repose showed a cohesion phenomenon and some bridges formed between particles of undried 80% moisture content MCC ball-milled for 12 h. Without adding SiO2, our MCC gained improved binding properties, a balance between flowability and tabletability, and a more useful controlled-released ability compared with commercial MCC and SMCC.
更多查看译文
关键词
self-lubricating
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要