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Involvement of CacyBP/SIP in differentiation and the immune response of HaCaT keratinocytes

Wiesława Leśniak,Anastasiia Bohush,Małgorzata Maksymowicz, Cezary Piwowarczyk,Natalia Katarzyna Karolak,Ewelina Jurewicz,Anna Filipek

Immunobiology（2023）

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Abstract
•CacyBP/SIP is expressed in human HaCaT keratinocytes.•CacyBP/SIP promotes epidermal differentiation.•Poly(I:C) treatment induces antiviral immune response in HaCaT cells.•CacyBP/SIP knockdown attenuates STAT1 signaling and expression of antiviral proteins.•CacyBP/SIP is involved in the antiviral response of human keratinocytes.
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Key words
keratinocytes,cacybp/sip,immune response
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