A novel and sustainable pipette-tip solid-phase microextraction testing of six carbon-based nanomaterials as proof of concept for the determination of sixteen emerging pollutants from active veterinary principles

•The carbon-based nanomaterials used as sorbents showed excellent performance for MSPE.•The use of RSM allows us to optimize the mass and pH for each NM.•The continuous methodology has advantages over the batch method for the determination of multianalytes.