Exosomes-delivered PD-L1 siRNA and CTLA-4 siRNA protect against growth and tumor immune escape in colorectal cancer

Jian Li,Yuxiang Chen,Mingmei Liao,Shuyi Yu,Binwen Yuan,Zeming Jia,Lin Zhou,Yaping Tang

Genomics（2023）

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摘要

•PD-L1 and CTLA-4 expression is high in CRC cells.•Exosomes containing PD-L1 and CTLA-4 siRNA inhibit CRC cell proliferation.•Exosomes containing PD-L1 and CTLA-4 siRNA repress immune escape of CRC cells.•Exosomes containing PD-L1 and CTLA-4 siRNA suppress CRC growth in vivo.•Exosomes containing PD-L1 and CTLA-4 siRNA activate tumor immune response in vivo.

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关键词

PD-L1,CTLA-4,siRNA,Colorectal cancer,Immune activation

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