Anti-oxidative and anti-aging effects of mannoprotein-rich yeast cell wall enzymatic hydrolysate by modulating gut microbiota and metabolites in Caenorhabditis elegans

•The C. elegans model was designed using mannoprotein-rich yeast cell wall enzymatic hydrolysate (MYH).•Antioxidant enzymes were the key enzymes in extending the lifespan and anti-stress ability.•Related mRNA played an important role in exerting antioxidant and anti-aging activities.•Gut microbiota and metabolites contributed to the antioxidant and anti-aging activities.