Food-inspired peptides from spinach Rubisco endowed with antioxidant, antinociceptive and anti-inflammatory properties

Lorenza Marinaccio,Gokhan Zengin,Stefano Pieretti,Paola Minosi,Edina Szucs,Sandor Benyhe,Ettore Novellino,Domiziana Masci,Azzurra Stefanucci,Adriano Mollica

Food Chemistry: X（2023）

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摘要

•Rubiscolin-6 is a linear peptide isolated by the spinach Rubisco.•New analogues have been prepared via SPPS with high purity and good overall yields.•Their activity on opioid receptors has been detected in vitro and in vivo.•Some of them possess a strong antioxidant and tyrosinase inhibitor activity.•Peptide LMAS6 exerts also a significant anti-inflammatory in vivo.

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关键词

Rubiscolin-6, Rubisco, Antioxidants, Anti -browning agent, Nutraceuticals

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