IDF2022-0337 Maternal and Neonatal Morbidity and Mortality Among COVID-19 positive Pregnant Women with and Without GDM

At the beginning of the COVID-19 pandemic, the precise extent of the risks in pregnancy was uncertain. Because of the known deleterious effects of COVID-19 in patients with diabetes, we need to assess the risk imposed by COVID-19 on maternal and neonatal outcomes in GDM pregnant women with COVID-19. To evaluate the risks associated with COVID-19 & GDM in pregnancy on maternal and neonatal outcomes. This is a cohort study that took place over 1 year during covid-19 pandemic in one centre. COVID-19 infected pregnant women, with or without Gestational Diabetes Mellitus were identified. They were included regardless of gestational age and type of delivery. Women and neonates were followed up until discharge from hospital. A total of 314 pregnant women with COVID-19 were enrolled, all with broadly similar demographic characteristics. GDM was diagnosed in 95 women (30.3%). Women with GDM and COVID-19 were at higher risk for pregnancy complications: Euglycemic DKA.preeclampsia/eclampsia, severe infections (88.4%), intensive care unit admission (29.5%), maternal mortality (1.2%), preterm birth (18.9%), medically indicated preterm birth (1.1%), severe neonatal morbidity index (8.4%). Non GDM women with COVID-19 diagnosis remained at higher risk only for maternal morbidity (2.2%), Intensive care unit admission (11.8%), preterm birth (26.4%), severe neonatal morbidity index (2.8%). Fever and shortness of breath for any duration were associated with an increased risk of severe maternal complications (65.3%) and neonatal complications (8.4%) in GDM, where in non GDM was reduced the risk for maternal complications (35.4%) and as well for neonatal complications (2.8%). In this cohort study, COVID-19 and GDM were associated with a consistent and substantial increases in severe maternal morbidity and mortality and neonatal complications when pregnant women infected with COVID-19 diagnosed. The findings should alert clinicians as well as pregnant women to strictly implement all the recommended COVID-19 preventive measures including vaccination against COVID-19.