Quo Vadis? Outcomes at a young adult to pediatric transition program

protein abundance index (emPAI).ANOVA was utilized to filter proteins that were enriched in MBGC samples versus sediment lacking MBGC or urine supernatant.Summary of Results: A total of 3367 proteins were identified across all MBGC samples (mean ± SD = 1976 ± 243 proteins/sample).The most abundant proteins in MBGC samples were Ig kappa constant region and retinol-binding protein 4.Although abundant, uromodulin had a mean rank of 15 across all MBGC samples.A total of 272 proteins were higher in MBGC compared to urine supernatant or control sediment without MBGC.Only one protein was exclusive to all MBGC samples, adrenodoxin, a small 19 kDa iron-binding mitochondrial protein known to be expressed in kidney tubules.A second protein, PDZ/ LIM domain protein 1 was exclusive to 11 out of 12 MBGC samples and is involved in cytoskeletal stress fiber assembly in fibroblasts.Conclusions: Mitochondrial adrenodoxin (ferrodoxin) and PDZ/LIM domain protein 1 may constitute a biomarker of MBGC presence and serve an alternative method to urine microscopy for identifying the presence of MBGC.We conclude that urinary adrenodoxin and PDZ/LIM domain protein 1 are potential target proteins for ATI diagnosis.