Bioinspired medical indwelling catheters with hierarchically structured coatings exhibiting specific wettability and antibacterial property

The use of medical indwelling catheters in conjunction with implantable medical devices has saved countless lives in various medical procedures. However, biofilm formation on catheter surfaces remains a persistent problem that can lead to chronic infections and device failure. Current approaches to addressing this issue involve the use of biocidal agents or self-cleaning surfaces, but these methods are limited in their effectiveness. Superwettable surfaces have shown great promise in preventing biofilm formation by manipulating the adhesive properties between bacteria and catheter surfaces. In this study, we present a novel medical indwelling catheter with hierarchically structured coatings that exhibit specific wettability and antibacterial properties. By integrating the hierarchical structure and specific wettability, we have developed an indwelling catheter with high flexibility and self-cleaning ability, which is very promising in biomedical engineering applications. Our approach draws inspiration from natural examples, such as the compound eyes of mosquitoes and lotus leaves, and represents a significant step forward in the development of effective anti-infection strategies for medical indwelling catheters.